This paper investigates the use of organizational structure and management control systems as interdependent variables to drive strategic change. We use an in-depth longitudinal case study of Henkel, a German multinational company, from 2008 through 2013. We document how changes to the entrepreneurial gap—defined as the difference between the span of control as determined by organizational structure and span of accountability as set by diagnostic control systems—contributed to the subsequent entrepreneurial orientation of the organization. This gap supports the purposeful misalignment between objectives pursued and resources controlled that entrepreneurship theory argues as a fruitful way for larger companies to reinforce entrepreneurial behavior. The findings offer a complementary structural perspective on strategic change beyond organizational identity, knowledge, capabilities, and narratives.