Obesity-related type 2 diabetes (T2D) has a multi-organic component both from an etiology and pathology perspective. Genetic variation in combination with diabesogenic environmental variation will explain the diversity in patient phenotypes. Thus, one of the major challenges it is the correct characterization and understanding of the different phenotypes to achieve a better stratification and personalized treatment.
Our group is working in an ambitious animal study (LiMa study) designed to assess systemically and organ specific metabolic plasticity in the context of obesity-related T2D. The phenotypical and functional characterization of our experimental groups and the number of mice evaluated help us to uncover complex tissue-specific responses under the same diabesogenic environment. This presentation will be focused on the loss of metabolic plasticity in white adipose tissue.