The 3D architecture of chromosomes
DBC Seminar with Dr. Mario Nicodemi
Thursday 2 April 2020 (12h15 - 13h00) - Génopode - Auditoire A
I review recent technological progresses to investigate chromosome 3D organisation and its functional role at the single-molecule level. Next, I discuss how principled approaches from polymer physics are helping to make sense of the physical and molecular mechanisms underlying chromatin folding and contact patterns. Finally, I show that polymer physics can be used to predict the impact of large mutations (Structural Variants) on chromosome structure, in particular on how the network of contacts between genes and regulators is rewired, hence enabling the identification of their pathogenic potential.