Renal regulation of water and sodium metabolism is one of the most fundamental homeostatic functions in man. Li salts are used drugs for treating patients with bipolar affective disorders.
Li negatively affects the ability of the kidney to concentrate urine, and patients may develop Nephrogenic Diabetes Insipidus. This is associated with downregulation of AQP2, a change in the cellular composition of the kidney and an activation of MAPK signaling pathways. We have investigated mechanisms behind these changed parameters and potential drugs for treatment. Aldosterone plays a key role in regulation of sodium reabsorption in the cells of the distal nephron. We have identified mediators of chronic aldosterone action in the distal tubule cells by RNA sequencing.