During aging, brain undergoes a progressive decline in neuronal functions that leads to cognitive and metabolic impairments. With increased life expectancies, the number of individuals affected by age-related memory loss is bound to dramatically increase. Elucidating the cellular and molecular mechanisms involved in brain aging is crucial and could provide the foundation for novel therapeutic strategies to prevent/improve age-related physiological disorders.
Our recent work reveals that maintaining hormonal balance is essential to ensure proper neuronal homeostasis both in hippocampus and hypothalamus. Exploring the molecular and cellular events mediating this effect, we found that autophagy machinery is a key player for the convergence of hormonal factors on neurons to promote cognition and maintenance of energy metabolism.
We will present here novel regulatory mechanisms modulating neuronal autophagy during aging and allowing the autophagy machinery to transduce the effects of the systemic milieu in neurons to foster cognitive and metabolic fitness.
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Also available via Zoom: https://unil.zoom.us/j/7437396231