Departmental seminar
Abstract:
Oxytocin orchestrates social and emotional behaviors through modulation of neural circuits in brain structures such as the central amygdala (CeA). In this structure, the release of oxytocin modulates inhibitory circuits and subsequently suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function approaches and pharmacology, we demonstrate that oxytocin signaling in the central amygdala relies on a subpopulation of astrocytes that represent a prerequisite for proper function of CeA circuits and adequate behavioral responses, both in rats and mice. Our work identifies astrocytes as crucial cellular intermediaries of oxytocinergic modulation in emotional behaviors related to anxiety or positive reinforcement. To our knowledge, this is the first demonstration of a direct role of astrocytes in oxytocin signaling and challenges the long-held dogma that oxytocin signaling occurs exclusively via direct action on neurons in the central nervous system.
Further reading:
Wahis J, et al. Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents. Nature Neuroscience 2021 24(4):529-541. doi: 10.1038/s41593-021-00800-0.
Also available via Zoom:
https://unil.zoom.us/j/94787206040