From Molecular Codes to Behavioral Patterns: Deciphering Autism Spectrum Disorders
Recent advancements in the field of autism spectrum disorder (ASD) research have uncovered an array of genes associated with the risk of developing this complex condition, shedding light on crucial biological pathways.
Despite this progress, critical questions remain unanswered, particularly regarding the mechanisms through which genetic mutations translate into ASD and the reasons behind the phenotypic similarity across different genetic forms of the disorder. Addressing these questions is not only pivotal for ASD understanding but can also unravel fundamental principles of brain function and development. In this presentation, I will introduce our integrative strategy that goes from single- cell sequencing to comprehensive functional studies, aiming to dissect a diverse array of ASD models. This approach is designed to reveal both convergences and divergences across various forms of autism, providing insights into the common and unique molecular pathways that underlie this spectrum of disorders.
Prof. Rosa Chiara Paolicelli