A flexible new model of gene family evolution
Céline Sconavacca is graduated in mathematical engineering at the University of Rome in 2006. she received her Ph.D. in Computer Science from the University of Montpellier in 2009. After a postdoctoral position at the University of Tübingen (Germany), she joined the Institut des Sciences de l’Evolution de Montpellier (ISEM) as CNRS research associate in October 2011. Her research interests include parameterized complexity, supertree and network methods for phylogenetics, combinatorics and bioinformatics.
Thursday 27 February 2020 (12h15 - 13h00) - Génopode - Auditoire A
An accurate model of gene family evolution within species is fundamental to infer the history of a gene family, and numerous such models have been proposed in the literature, often in the context of gene tree-species tree reconciliations.
The two main classes of models account for either (a) gene duplication, transfers, and losses, or (b) population-level processes resulting in incomplete lineage sorting.
A few models have been proposed that include all of these processes, but make some unrealistic simplifying assumptions. Particularly, no existing model correctly accounts for hemiplasy of duplicated loci and for the fact that evolution of duplicated loci maybe partially related, due to the absence (or presence) of recombination between the loci. In this talk, I will discuss a new gene family evolution model, IxDTL, which models all these processes and also allows hemiplasy and(partial) dependency of duplicated loci. This allows to model more complex and realistic scenarios than previously allowed, thus providing a new powerful setting for proper simulation of gene families.